Supply Notice – Salofalk (mesalazine) 500mg and 1g suppositories

Supply Notice – Salofalk (mesalazine) 500mg and 1g suppositories

November 1, 2019

Ref: MSN/2019/003
Tier 2 – medium impact
Date of issue 1 November 2019

Further to the recent shortage notice regarding Salofalk, the Department of Health and Social Care have today provided the following update.


  • Salofalk® 500mg suppositories are out of stock until w/c 16th December 2019.
  • Salofalk® 1g suppositories will be out of stock from late November until w/c 16th December 2019.
  • Pentasa® (mesalazine) 1g suppositories remain available during this period.

Actions Required

  • For patients without sufficient supplies of Salofalk® suppositories to last until the resolution date, prescribers may consider switching to Pentasa®
  • The below table can be used to support dose conversion between brands:
Salofalk®: Existing regimen Pentasa®: Proposed regimen
1g daily 1g daily
500mg twice daily 1 g daily
500mg three times daily Either 1 g daily (within licence) or 1g twice daily (off label)
2 x 500mg suppositories twice daily 1g twice daily (off label)
2 x 500mg suppositories three times daily 1g three times daily (off label)
  • Clinicians (both prescribing and dispensing) should counsel patients regarding the different dosing regimen prescribed, where appropriate.

Supporting Information


If you have any queries, please contact

For more information on medicines shortages, click here.

To report a medicine shortage, click here.

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