Shortage Notice: Seroxat (paroxetine) 20mg/10ml oral solution

Shortage Notice: Seroxat (paroxetine) 20mg/10ml oral solution

October 25, 2019

The Department of Health and Social Care (DHSC) have advised that paroxetine 20mg/10ml oral solution will be out of stock until January 2020 due to manufacturing delays. Paroxetine tablets remain available from various suppliers.

Action required: 

For patients who do not have sufficient supplies of paroxetine 20mg/10ml oral solution for the duration of the expected out of stock period, clinicians should consider the alternatives below as soon as possible.

  • Prescribing paroxetine tablets in place of oral solution.
  • UK Medicines Information (UKMi) have advised that tablets can be crushed and mixed with water for administration, however this would be an off-label use. The crushed tablets are bitter and have a slight local anaesthetic effect.
  • Prescribing an unlicensed preparation of paroxetine 20mg/10ml oral solution, which is currently available to order from the following importers – Clinigen, WEP Clinical, Mawdsleys and Target Healthcare Ltd.
  • Clinicians will need to work with local pharmacies to understand which specific unlicensed products can be sourced and lead times. The price of specials varies.

Pharmacy team are reminded that where a prescriber wishes you to dispense an import, prescriptions must be annotated ‘specials/unlicensed import’.

A prescription calling for the unlicensed product should be endorsed as follows:

  • Quantity dispensed
  • Pack size
  • Price per unit less any discount/rebate
  • Manufacturer/importer MHRA license number
  • Batch number
  • Specials procurement fee endorsement of ‘SP’

As a reminder, all prescriptions for unlicensed medicines should be placed in the red separators for the end of month submission.

See our factsheet for further guidance on endorsing unlicensed specials and imports.

For more information on medicines shortages, click here.

To report a medicine shortage, click here.

If you have any queries, please contact DHSCmedicinesupplyteam@dhsc.gov.uk



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