Shortage Notice: Salofalk (mesalazine) suppositories (500mg and 1g) – Update

Shortage Notice: Salofalk (mesalazine) suppositories (500mg and 1g) – Update

February 20, 2020

Update (20/02/2020): resupply date now expected mid April 2020 for the 500mg suppositories, mid September 2020 for the 1g suppositories


First published 24th October 2019

Dr Falk the sole supplier of the 500mg mesalazine suppository (Salofalk suppositories 500mg) has announced that they expect to be out of stock of this line until mid-December 2019. The company also expect to be out of stock of the 1g suppository (Salofalk suppositories 1g) from late November to mid-December.

Alternative agents and management options
The guidance issued states ‘NICE support the first-line use of topical aminosalicylates (including mesalazine suppositories) to induce remission in people with a mild-to-moderate first presentation or inflammatory exacerbation of ulcerative proctitis. They also recommend that a topical aminosalicylate (daily or intermittent) should be considered to maintain remission after a mild-to-moderate exacerbation of ulcerative proctitis.

In the absence of Salofalk suppositories the most practical short-term management option is to convert patients to Pentasa suppositories. For patients being treated with the 1g strength this is a straight forward conversion – the dose regimen is identical for both brands.
However, for patients being treated with the 500mg strength it is less straight forward – patients could be receiving doses ranging from 500mg twice daily through to 1 g three times a day.’ 

Suggested dose changes are as follows*

Existing regimen Proposed regimen Proposed regimen
500mg twice daily 1 g daily
500mg three times daily Either 1 g daily (within licence) or 1g twice daily (off label)
2x500mg suppositories twice daily 1g twice daily (off label)
2x500mg suppositories three times daily 1g three times daily (off label) 1g three times daily (off label)

*as per the UKMi memo 

View the full memo on the Specialist Pharmacy Service website here.

For more information on medicines shortages, click here.

To report a medicine shortage, click here.



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